Record Display for the EPA National Library Catalog
RECORD NUMBER: 4 OF 243
|OLS Field Name||OLS Field Data|
|Main Title||A short-term method for assessing the reproductive toxicity of endocrine-disrupting chemicals using the fathead minnow (Pimephales promelas) /|
|Author||Mid-Continent Ecology Division.|
|CORP Author||National Health and Environmental Effects Research Lab., Duluth, MN. Mid-Continent Ecology Div. (Duluth) Library.|
|Publisher||National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Office of Research and Development, U.S. Environmental Protection Agency,|
|Subjects||Endocrine disrupting chemicals--Toxicology. ; Fathead minnow. ; Reproductive toxicology.|
|Additional Subjects||Reproductive toxicity ; Assessment ; Fathead minnow ; Manuals ; Test methods ; Chemicals ; Estrogens ; Androgens ; Endpoint ; Reproductive behavior ; Fecuncity ; Fertility ; Procedures ; Measurements ; Short-term test method ; Endocrine-disrupting chemicals ; Endocrine pathways ; Adult survival ; Secondary sex characteristics ; Gonadosomatic ; Gonadal histology ; Plasma concentrations ; Vitellogenin ; Sex steroids|
|Collation||xi, 154 pages : illustrations ; 28 cm|
This manual describes a test method with the fathead minnow suitable for assessing potential reproductive effects of chemicals, with an emphasis on endocrine pathways controlled by estrogens and androgens. The test is conducted with reproductively-mature animals for 21 d. Endpoints assessed include: adult survival, reproductive behavior, secondary sex characteristics, gonadosomatic index, gonadal histology, plasma concentrations of vitellogenin and sex steroids (beta-estradiol, testosterone, 11-ketotestosterone), fecundity, fertility, and if desired, F(sub 1) viability. In addition to describing the test method, guidance is presented as to interpretation of test results with respect to identifican of potential endocrine-disrupting chemicals.
"June 2002." Includes bibliographical references (pages 98-107). "EPA/600-R-01-067." Includes appendices "A-E" (p. 108-147).