Record Display for the EPA National Library Catalog

RECORD NUMBER: 43 OF 49

OLS Field Name OLS Field Data
Main Title Octanol/Water Partition Coefficients and Aqueous Solubilities of Organic Compounds.
Author Wasik, Stanley P. ; Tewari, Yadu B. ; Miller, Michele M. ; Matire, Daniel E. ;
CORP Author National Bureau of Standards, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1981
Report Number NBSIR-81-2406;
Stock Number PB82-141797
Additional Subjects Solubility ; Organic compounds ; Water ; Gas chromatography ; Partition coefficients ; Octanols ; High pressure liquid chromatography ; Numerical solution
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB82-141797 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 68p
Abstract
A generator column method for measuring the octanol/water partition coefficient, K(o/w) and the aqueous solubility, C sup w sub s, is described. When water is pumped through a generator column packed with solid support coated with an organic stationary phase, an aqueous solution is generated that is in equilibrium with the stationary phase. The solute concentration in the eluted aqueous phase was measured either by high pressure liquid chromatography or by solvent extraction followed by gas chromatographic analysis. Aqueous solubilities and octanol/water partition coefficients of organic solutes, falling into 7 general chemical classes, have been systematically determined using the modified generator column method. From thermodynamics an equation is derived relating K(o/w) to the volume-fraction-based solute activity coefficient in water gamma sup w sub s, the latter being determinable from C sup w sub s. For each class of compounds, excellent linear correlations are found between log K(o/w) and log gamma sup w sub s with slopes close to the theoretical value of unity.