Eight analytical methods covering 133 organic contaminants which may be present in drinking water or drinking water sources are described in detail. These methods will give the laboratory analyst the capability to accurately and precisely determine organic compounds currently regulated in drinking water, designated for regulation by the Office of Ground Water and Drinking Water in the near future, or are potential candidates for regulatory concern. The only method to determine volatile organic compounds in the manual, Method 524.2, Revision 4.0, has 24 new analytes added to the method analyte list. Four of the eight methods are improvements over older existing methods, and employ new analytical techniques, such as liquid-solid extraction, to improve method performance and reduce the use of organic solvents. Three of the methods are new methods for the determination of semivolatile compounds, one for ozonation disinfection by-products, one for phenoxyacid herbicides using the novel approach of in-line extraction/high performance liquid chromatography (HPLC), and one for nonvolatile compounds using particle beam HPLC/MS.