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RECORD NUMBER: 280 OF 1150

OLS Field Name OLS Field Data
Main Title Effects of o,p'-DDT on the Adrenal Gland and Hepatic Microsomal Enzyme System in the Beagle Dog.
Author Copeland, M. F. ; Cranmer., M. F. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Primate and Pesticide Effects Lab.
Year Published 1973
Stock Number PB-279 721
Additional Subjects Insecticides ; DDT ; Pesticides ; Toxicology ; Dogs ; Enzymes ; Liver ; Ribosomes ; Adrenal gland ; Ingestion(Biology) ; Laboratory animals ; Experimental data ; Physiological effects ; Tables(Data) ; Tissues(Biology) ; Distribution ; Storage ; Adrenal cortex ; Herbicides ; Reprints ; Toxic substances ; DDD insecticide ; Bioaccumulation
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-279 721 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 10p
Abstract
Four male beagle dogs received o,p'-DDT (50 mg/kg/day) in corn oil, administered in gelatin capsules, for 32 days. Four dogs used as controls received only corn oil. The treated dogs maintained body weights comparable to the controls and there were no overt signs of toxicity. The treated dogs showed a decreased eosinopenic response to ACTH after day 16. There was no significant difference in the plasma sodium and potassium concentrations or in the hematocrit before or after ACTH, nor in the 17-hydroxycorticosteroid (17-OHCS) response to ACTH between the treated and control dogs on any of the test days.