Record Display for the EPA National Library Catalog

RECORD NUMBER: 259 OF 1150

OLS Field Name OLS Field Data
Main Title Drinking Water Criteria Document for Simazine.
CORP Author Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Drinking Water.
Publisher May 90
Year Published 1990
Stock Number PB90-215344
Additional Subjects Potable water ; Toxicology ; Water quality ; Herbicides ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Simazine ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Chromosome aberrations
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-215344 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 85p
Abstract
Simazine is the common name for 2-chloro-4,6-bis(ethylamino)-1,3,5 triazine. The acute oral LD50 estimates are 5,000 mg/kg or higher in rats, mice, rabbits, and birds, but a dose of 500 mg/kg has been reported to be lethal in sheep. Pharmacotoxic signs in sheep included incoordination, tremors, weakness, cyanosis, and clonic convulsions. A dose of 4,200 mg/kg caused anorexia, weight loss, and some lethality in rats. In a three-generation reproduction study with Charles River rats fed simazine 80W in the diet at 50 or 100 ppm, a parental toxicity NOAEL of less than 50 ppm and a LOAEL of 50 ppm were identified based on reduced weight gains in males during the premating periods. In a teratology study with rats, simazine administered at high doses (1,250 and 2,500 mg/kg/day) during gestation days 6 through 15 delayed fetal development and was embryotoxic but not teratogenic. Most tests of mutagenic potential for simazine have been negative.