Record Display for the EPA National Library Catalog
RECORD NUMBER: 258 OF 1150
|OLS Field Name||OLS Field Data|
|Main Title||Drinking Water Criteria Document for Picloram.|
|CORP Author||Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Drinking Water.|
|Additional Subjects||Potable water ; Toxicology ; Water quality ; Herbicides ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Liver neoplasms ; Picloram ; Water pollution effects(Plants) ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Chromosome aberrations|
Picloram (4-amino-3,5,6-trichloropicolinic acid) is a widely used herbicide available in a number of formulations under the trade name Tordon. Almost no information was found in the available literature regarding the effects of picloram on humans. Picloram is poorly absorbed through human skin, and dermal application does not produce sensitization. The mechanism of picloram toxicity in animals has not been investigated. Its herbicidal effectiveness is a consequence of its auxin-like activity, which causes abnormal plant growth and development. In animals, no clear synergistic interactions of picloram with other chemicals have been observed.