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RECORD NUMBER: 253 OF 1146

OLS Field Name OLS Field Data
Main Title Drinking Water Criteria Document for Diquat.
CORP Author Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Drinking Water.
Publisher Apr 90
Year Published 1990
Stock Number PB90-215377
Additional Subjects Potable water ; Toxicology ; Water quality ; Herbicides ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Free radicals ; Diquat ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Chromosome aberrations ; Lipid peroxidation ; Path of pollutants ; Mutagenicity tests
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-215377 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 95p
Abstract
Diquat is a dipyridylium herbicide that has been used extensively to control terrestrial and aquatic weeds. Diquat has moderate acute oral toxicity in mammals. Oral LD50 values for various species were between >26 (for dog) and 430 mg diquat (for rat) ion/kg bw. The most notable effects of oral doses were an increase in gastrointestinal water content and hemoconcentration. Diquat has a profound effect on body water distribution; dehydration may play a key role in mortality. The mutagenic potential of diquat was studied in a number of bacterial and eukaryotic systems. The results reported in the literature are contradictory. No antifertility or teratogenic effects were observed in mice, rats, or rabbits after oral diquat administration. However, teratogenic effects were observed when diquat was administered to rats and mice via intraperitoneal (ip) or intravenous (iv) injections.