Record Display for the EPA National Library Catalog

RECORD NUMBER: 30 OF 1196

OLS Field Name OLS Field Data
Main Title Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Potassium Picloram (Journal Version).
Author Hayes, J. R. ; Condie, L. W. ; Borzelleca, J. F. ;
CORP Author Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1986
Year Published 1986
Report Number EPA-R-808861; EPA/600/J-86/473;
Stock Number PB89-103998
Additional Subjects Toxic substances ; Toxicity ; Herbicides ; Picloram ; Mortality ; Laboratory animals ; Dose-response relationships ; Oral administration ; Pathology ; Central nervous system ; Liver ; Kidney ; Reprints ; Picolinic acid/amino-trichloro(Potassium salt)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB89-103998 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 10p
Abstract
Potassium picloram was administered either by gavage (acute studies) or in drinking water to male and female Sprague-Dawley derived rats (14-day and 90-day studies). The acute oral LD50 was 950 mg/kg (812-1120) for males and 686 mg/kg (599-786) for females. Depression, prostration, ataxia, tremors and convulsions preceded death. There were no consistent biologically significant compound related effects in rats that received 60, 190 or 600 mg potassium picloram/kg/day for 14 days. In the subchronic study, rats received 60, 190, 600 or 1070 mg potassium picloram/kg/day for 90 consecutive days. There were only 4 male and 2 female survivors out of 20 rats of each sex at the 1070 mg/kg dose and 16 male and 18 female survivors at the 570 mg/kg dose. Mortality was dose-dependent. No specific organ site toxicity could be identified in these studies. Toxicity from exposure to picloram in drinking water is apparently low. (Copyright (c) 1986 by the Society of Toxicology.)