Record Display for the EPA National Library Catalog

RECORD NUMBER: 1077 OF 1148

OLS Field Name OLS Field Data
Main Title Toxicity of Paraquat to Rats and Its Effect on Rat Lungs.
Author Kimbrough, R. D. ; Gaines., T. B. ;
CORP Author Food and Drug Administration, Chamblee, Ga.
Year Published 1969
Report Number found in PB-280 889
Stock Number PB-280 898, found in PB-280 889
Additional Subjects Herbicides ; Pesticides ; Toxicology ; Toxicity ; Rats ; Laboratory animals ; Experimental data ; Dosage ; Ingestion(Biology) ; Bioassay ; Lethal dosage ; Females ; Males ; Lung ; Tissues(Biology) ; Physiological effects ; Pathology ; Reprints ; Paraquat herbicide ; Bipyridinium/dimethyl ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-280 898 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 12p
Abstract
Acute and subacute toxicity studies were conducted with paraquat (1,1'-dimethyl-4,4'-dipyridylium dimethylsulfate) in adult Sherman rats. The single-dose oral LD50 was 100 mg.kg in females. The 90-dose oral LD50 in female rats was 21 mg/kg, giving a chronicity factor of 5.2. The acute dermal LD50 was 80 mg/kg in male rats and 90 mg/kg in females. Studies of lung tissue with the electron microscope after a single oral dose indicate that the first discernible changes are pulmonary edema, swelling of the epithelium, an increase in collagen, and an effect on the ribosomes of the membranous pneumocytes. Light microscopic studies of lungs affected by paraquat after po and iv administration or local instillation showed intra-alveolar hemorrhage, edema, extensive fibrosis, and changes in the epithelium. Local instillation of 0.05 mg/kg of paraquat into lung and 0.8 mg/kg into skeletal muscle caused local fibrosis.
Notes
contained in PB-280 889 titled Journal Articles on Toxicology. Group 14.