Record Display for the EPA National Library Catalog
RECORD NUMBER: 378 OF 1080Main Title | Hepatic Porphyria Induced by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in the Mouse. | |||||||||||
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Author | Goldstein, J. A. ; Hickman, P. ; Bergman, H. ; Vos., J. G. ; | |||||||||||
CORP Author | Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs. | |||||||||||
Year Published | 1973 | |||||||||||
Stock Number | PB-280 843 | |||||||||||
Additional Subjects | Herbicides ; Porphyria ; Pesticides ; Toxicology ; Nitrogen organic compounds ; Chlorine organic compounds ; Mice ; Metabolic diseases ; Liver ; Dosage ; Ingestion(Biology) ; Bioassay ; Lethal dosage ; Tables(Data) ; Laboratory animals ; Experimental data ; Physiological effects ; Contaminants ; Pathology ; Reprints ; Dioxin/tetrachloro-dibenzo ; Synthetases/aminolevulinate ; Porphyrin/carboxy ; Toxic substances | |||||||||||
Holdings |
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Collation | 10p | |||||||||||
Abstract | Oral administration of 4 weekly doses of 25 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin resulted in induction of delta-aminolevulinic acid synthetase and hepatic porphyria in mice. There was a 2,000-fold increase in the liver content of 8- and 7-carboxyporphyrins. A single lethal oral dose of 150 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin also resulted in a 4,000-fold increase in uroporphyrins in the liver. Doses of tetrachlorofibenzo-p-dioxin which resulted in porphyria also resulted in microscopic evidence of marked liver damage and a moderate increase in the total iron content of the liver. At this time, 2,3,7,8-tetrachlorodibenzo-p-dioxin, a contaminant of a variety of environmenal chemicals, is the most potent porphyrogenic chemical known. |