Record Display for the EPA National Library Catalog

RECORD NUMBER: 1 OF 3

OLS Field Name OLS Field Data
Main Title Influence of Time of Exposure to Carbon Tetrachloride on Toxic Liver Injury.
Author Bruckner, J. V. ; Luthra, R. ; Kyle, G. M. ; Muralidhara, S. ; Ramanathan, R. ;
CORP Author Georgia Univ., Athens. Dept. of Pharmacology and Toxicology. ;Texas Univ., Austin. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-811215; EPA/600/J-84/272;
Stock Number PB85-220424
Additional Subjects Toxicology ; Injuries ; Exposure ; Liver ; Rats ; Laboratory animals ; Reprints ; Carbon tetrachloride ; Hepatotoxins
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-220424 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 7p
Abstract
The study was conducted to determine whether, and by what mechanisms, time of exposure could influence the ability of a model hepatotoxin, carbon tetrachloride (CCl4) to cause liver injury. Rats dosed orally with CCl4 during their active/dark cycle were found to be more susceptible to liver injury than rats dosed during their inactive/light cycle. There was greater hepatic microsomal uptake and metabolism of CCl4 in rats dosed during their active cycle.