Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of duck hepatitis virus on pesticide toxicity /
Author Ragland, William Lauman, ; Ragland., W. L.
CORP Author Georgia Univ., Athens. Poultry Disease Research Center.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1976
Report Number EPA-600/1-76-003; EPA-R801800
Stock Number PB-249 351
OCLC Number 42786718
Subjects Virology--Research. ; DDT (Insecticide)--Research. ; Newcastle disease vaccine.
Additional Subjects Enzymes ; Liver ; Pesticides ; Hepatitis viruses ; Metabolism ; Induction ; Reticuloendothelial system ; DDT ; Tissues(Biology) ; Ducks ; Newcastle disease virus ; Drugs ; Bioaccumulation ; Pesticide residues
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJAD  EPA 600/1-76-003 Region 3 Library/Philadelphia, PA 01/14/2000
EJBD ARCHIVE EPA 600-1-76-003 Headquarters Library/Washington,DC 05/13/2013
EJBD  EPA 600-1-76-003 Headquarters Library/Washington,DC 01/17/2014
EKAM  EPA 600/1-76/003 Region 4 Library/Atlanta,GA 11/19/1999
EKBD  EPA-600/1-76-003 Research Triangle Park Library/RTP, NC 02/11/2000
ELBD  EPA 600-1-76-003 AWBERC Library/Cincinnati,OH 11/15/2016
ELDD  EPA-600/1-76-003 NHEERL/MED Library/Duluth,MN 12/01/2000
NTIS  PB-249 351 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation viii, 63 pages ; 28 cm.
The report presents the results of an investigation into the effect of viral replication on hepatic endoplasmic reticulum on the activities of the microsomal drug-metabolizing enzymes of liver. Two viruses which replicate on hepatic endoplasmic reticulum without producing hepatic disease were used. They were Newcastle disease vaccinal virus in chickens and duck hepatitis virus in adult ducks. The microsomal enzymes assayed were ethylmorphine N-demethylase, aryl hydrocarbon hydroxylase and anyline hydroxylase. The soluble enzyme, nitroreductase, also was assayed in chickens. Pesticide residue analysis was used to evaluate indirectly the microsomal enzymatic conversion of DDT to DDD and the soluble enzymatic conversion of DDT to DDE in ducks. Viral replication did not increase the activities of the microsomal enzymes and may have decreased the activities slightly. Although the microsomal enzymes were induced to greater levels by viral replication, pesticide residue analysis failed to demonstrate increased clearance of residues from body tissues.
"EPA-600/1-76-003." EPA grant no. R801800; EPA project officer: Ronald L. Baron. Includes bibliographical references (pages 59-61).