||Difference in Nitrosyl-Hemoglobin Formation Among Animal Species (Issakna Chisso Hemogurobin Seisei no Shuzokusa).
Oda, Hajime ;
Kusomoto, Shigeko ;
Nakajima., Taichi ;
||Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section.
Nitrogen oxide(NO) ;
Laboratory animals ;
Chemical reactions ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Nitrosyl-hemoglobin (NOHb) was detected by electron spin resonance spectrometry from the blood of mice and rats exposed to 7 ppm nitric oxide, but in rabbits it was detected only when sodium dithionite was added to the blood. To clarify this interspecific difference, some comparative experiments were conducted using the blood of mouse and rabbit. Rabbit blood showed higher affinity to oxygen and smaller production of NOHb after addition of nitrite compared to the mouse blood. These results may explain the reason NOHb was not detectable in rabbit blood during the exposure to nitric oxide.