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RECORD NUMBER: 38 OF 72

OLS Field Name OLS Field Data
Main Title Initial Submission: TSCA Health and Safety Study Cover Sheet w/Continuation Sheet re: Results of Rat Pilot Teratology Study with CMC (Confidential), Benzimidazolyl Heterocycle, dated 12/22/1999. (Sanitized).
CORP Author FMC Corp., Princeton, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1999
Report Number 8EHQ-1299-14621S
Stock Number OTS0559868
Additional Subjects Toxicology ; Health effects ; Rats ; Teratology ; Fetuses ; Females ; Reproduction(Biology) ; Body weight ; Food consumption ; Hematology ; Laboratory animals ; Research and development ; Gestation ; Benzimidazolyl heterocycle ; Carboxymethylcellulose(CMC)
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Status
NTIS  OTS0559868 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 04/28/2010
Collation 6p
Abstract
This study is being submitted due to the decreased fetal body weights seen at 5 mg/kg and greater and the increased early resorptions at 10 mg/kg and greater in the absence of maternal toxicity. Groups of eight mated female rats were adminstered (confidential) suspended in 1% carboxymethylcellulose (CMC) on days 6-19 of gestation. It is an experimental still in the R&D pre-commercialization phase. The dose levels were 0, 1.0, 3.0, 5.0, 10 and 30 mg/kg/day. Clinical observations were recorded daily; body weights and food consumption were recorded at three-day intervals. Prior to c-section, blood was collected for hematology determinations. A c-section was performed on each dam. Fetuses were weighed, sexed and examined for external alterations.