Record Display for the EPA National Library Catalog
RECORD NUMBER: 201 OF 1338
|OLS Field Name||OLS Field Data|
|Main Title||Chronic Toxicity of Lead and Cadmium: III. Effects of Chronic Intoxication on the Reproductive Function of the F1 Generation of Rats and on the Central Nervous System of the F2 Generation.|
|Author||Herman, Z. S. ; Kmieciak-Kolada, K. ; Szkilnik, R. ; Felinska, W. ; Slominska, J. ;|
|CORP Author||Slaska Akademia Medyczna, Katowice (Poland).;Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toxicology ; Lead(Metal) ; Cadmium ; Diets ; Ingestion(Biology) ; Physiological effects ; Bioassay ; Reproduction(Biology) ; Central nervous system ; Rats ; Laboratory animals ; Exposure ; Concentration(Composition) ; Heavy metals ; Drinking water ; Toxic substances|
Wistar rats, decended from animals used in previous toxicity studies, were administered lead and cadmium via drinking water and examined for changes in locomotor activity, neurochemical levels in various brain regions, concentrations of heavy metals in liver and kidney, blood components and reproductive ability and viability of offspring. Locomotor activity was seen to vary greatly but erratically after heavy metal treatment. Neurotransmitter levels also showed wide variations in response to heavy metal exposure, with the most notable being increases in noradrenaline in the hypothalamus and dopamine in the striatum. Weight gains during gestation, litter sizes, survival of offspring and average size of surviving offspring were all depressed in groups of treated animals, and eye-opening was delayed in these progeny groups.