Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Thermoregulation at a High Ambient Temperature Following the Oral Administration of Ethanol in the Rat.
Author Gordon, C. J. ; Mohler, F. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/285;
Stock Number PB91-145037
Additional Subjects Body temperature regulation ; Ethanol ; Toxicity ; Heat stress ; Rats ; Oxygen consumption ; Animal behavior ; Oral administration ; Metabolism ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-145037 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/13/1991
Collation 7p
The study was designed to assess the thermoregulatory mechanisms responsible for the elevation in body temperature following ethanol administration when exposed to a high ambient temperature (Ta). Male rats of the Fischer 344 strain were gavaged with 20% ethanol at doses of 0, 2.0, 4.0, 6.0, or 8.0 g/kg and were then placed in an environmental chamber set at a Ta of 37 C. Oxygen consumption (metabolic rate), evaporative water loss (EWL), and activity recorded for 60 min. Colonic temperature was measured at the end of the 60 min period. Ethanol at doses of 2.0 g/kg and greater caused significant reductions in activity. EWL was significantly depressed at doses > 4.0 g/kg. Colonic temperature of animals given 6.0 and 8.0 g/kg was significantly greater than controls. Oxygen consumption was unaffected by ethanol dose. Visual observation of the behavior of the ethanol treated rats indicated that animals given doses > 4.0 g/kg were unable to groom saliva onto their fur which would contribute to the reduction in EWL in the heat.