Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Role of Beta-Endorphin in the Control of Body Temperature in the Rabbit.
Author Gordon, C. J. ; Rezvani, A. H. ; Heath, J. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Illinois Univ. at Urbana-Champaign. Dept. of Physiology and Biophysics.
Year Published 1984
Report Number EPA/600/J-84/147;
Stock Number PB85-124477
Additional Subjects Thermoregulation ; Skin temperature ; Neuron activity ; Heat loss ; Rabbits ; Laboratory animals ; Metabolism ; Behavior ; Reprints ; Endorphin
Library Call Number Additional Info Location Last
NTIS  PB85-124477 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 11p
There is evidence of release of the opioid peptide beta-endorphin (beta-E) in the hypothalamus during development of fever and stress-induced hyperthermia. In the unanesthetized rabbit microinjection of beta-E in the preoptic/anterior hypothalamus (POAH) results in peripheral vasoconstriction, inhibition of evaporative heat loss, and a prolonged elevation of body temperature. These reactions are magnified with increases in ambient temperature. Injections of beta-E nearly abolish vasodilation to back heating and also postural enhancement of heat dissipation (sprawling, limb extension) in a hot environment. Beta-E has also been found to reduce the thermal sensitivity of single POAH neurons to ambient heating. However, POAH beta-E injections do not alter metabolic rate at ambient temperatures from 2 to 27 C, and to this extent beta-E-induced hyperthermia is distinct from fever. It is suggested that beta-E reduces sensitivity of POAH neurons to high ambient temperature and that this reduction leads to increased peripheral vasoconstriction, inhibition of evaporative heat loss, and modification of behavioral thermoregulation resulting in a regulated-type elevation in body temperature. A general neural model is proposed to explain the thermoregulatory effects of beta-E in the rabbit.