||Acute and Subchronic Inhalation Exposures of Hamsters to Nickel-Enriched Fly Ash.
Wehner, Alfred P. ;
Moss, Owen R. ;
Milliman, Edward M. ;
Dagle, Gerald E. ;
Schirmer, Roger E. ;
||Battelle Pacific Northwest Labs., Richland, WA. Biology Dept.;Health Effects Research Lab., Cincinnati, OH.
Fly ash ;
Laboratory animals ;
Air pollution effects(Animals) ;
Toxic substances ;
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One 6-hr inhalation exposure of hamsters to Ni-enriched fly ash (NEFA) aerosol (respirable aerosol concentration approx. 200 micrograms/liter) deposited about 80 micrograms in the deep lung, of which 75 micrograms was still present 30 days postexposure. The animals tolerated the exposure well during the 30-day postexposure observation period. Two-month exposures of hamsters to NEFA or fly ash (FA) aerosols (approx. 185 micrograms/liter) resulted in a deep lung burden of about 5.7 mg, dark discoloration of lungs, heavily dust-laden macrophages, and significantly higher lung weights than in controls, but only minimal inflammatory reaction and no deaths. There was no difference between NEFA and FA effects. The NEFA contained 9% Ni; FA contained 0.03% Ni. The results of this study indicate low acute and subchronic toxicity and slow lung clearance of NEFA and FA.