||Effect of In vivo Ozone Exposure to Dorset Sheep, an Animal Model with Low Levels of Erythrocyte Glucose-6-Phosphate Dehydrogenase Activity (Journal Version).
Moore, G. S. ;
Calabrese, E. J. ;
Schulz, E. ;
||Massachusetts Univ., Amherst. Div. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Air pollution effects(Animals) ;
Glucosephosphate dehydrogenase deficiency
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Female Dorset sheep were exposed in vivo to ambient ozone levels of 0.12 ppm, 0.25 ppm, 0.50 ppm, 0.70 ppm for 2.75 hours and the effects of this exposure upon erythrocytes were studied. Ozone exposure induced biochemical evidence of oxidant stress as indicated by decreases in reduced glutathione (GSH) levels (at 0.5 and 0.7 ppm ozone) and acetylcholinesterase (at 0.7 ppm), increases in methemoglobin (from 0.12 ppm upward) and decreases in red blood cell counts (0.12 ppm upward). However, only the decrease in GSH levels at the 0.5 ppm ozone exposure was statistically significant (p=0.05). (Copyright (c) 1984 by Chem-Orbital.)