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RECORD NUMBER: 20 OF 48

OLS Field Name OLS Field Data
Main Title Evaluation of the Dorset Sheep as a Predictive Animal Model for the Response of Glucose-6-Phosphate Dehydrogenase-Deficient Human Erythocytes to a Proposed Systemic Toxic Ozone Intermediate, Methyl Oleate Ozonide.
Author Calabrese, E. J. ; Williams, P. S. ; Moore, G. S. ;
CORP Author Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-805797; EPA/600/J-83/274;
Stock Number PB85-173193
Additional Subjects Ozone ; Hemoglobins ; Toxicology ; Erythrocytes ; Blood cells ; Humans ; Sheep ; Reprints ; Dehydrogenase/glucose-phosphate ; Oleic acid/methyl-ozonyl ; Animal models ; Glutathiones
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-173193 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
Erythrocytes of both glucose-6-phosphate dehydrogenase (G-6-PD)-deficient humans and Dorest sheep, an animal model with an erythrocyte G-6-PD deficiency, responded in a dose-dependent manner to the oxidant stress of methyl oleate ozonide (MOO) as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels, and decreases in GSH. However, the human G-6-PD-deficient erythrocytes were considerably more sensitive to the formation of METHB than the sheep erythrocytes while the reverse was the case for the GSH parameter. The results suggest a qualitative difference in the response of sheep erythrocytes and human G-6-PD-deficient erythrocytes to MOO that seriously questions the value of the sheep erythrocyte as a quantitatively accurate predictive model. (Copyright (c) 1983 by Academic Press, Inc.)