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RECORD NUMBER: 10 OF 48

OLS Field Name OLS Field Data
Main Title Effect of Methyl Linoleate Hydroperoxide (MLHP), A Possible Toxic Intermediate of Ozone, on Human Normal and Glucose-6-Phosphate Dehydrogenase (G-6-PD) Deficient Erythrocytes.
Author Williams, P. S. ; Calabrese, E. J. ; Moore, G. S. ;
CORP Author Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-805797; EPA/600/J-83/277;
Stock Number PB85-177855
Additional Subjects Erythrocytes ; Ozone ; In vitro analysis ; Air pollution ; Oxidation ; Chemical reactions ; Public health ; Exposure ; Reprints ; Chemical reaction mechanisms ; Air pollution effects(Humans) ; Dehydrogenase/glucose-phosphate ; Linoleic acid/(methyl-ester)-hydroperoxy
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-177855 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 14p
Abstract
Erythrocytes of both normal and G-6-PD deficient humans responded in a dose-dependent manner to the oxidant stress of MLHP as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels and decreases in reduced glutahione (GSH). The G-6-PD deficient erythrocytes displayed a markedly enhanced sensitivity to MLPH induced decreases in G-6-PD activity and METHB increases while being less sensitive than normal erythrocytes to changes in GSH levels. (Copyright (c) 1983 by Marcel Dekker, Inc.)