Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 22

OLS Field Name OLS Field Data
Main Title 5,7-Dihydroxytryptamine Injections Increase Glial Fibrillary Acidic Protein in the Hypothalamus of Adult Rats.
Author Frankfurt, M. ; O'Callaghan, J. ; Beaudet, A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Rockefeller Univ., New York. Lab. of Neuroendocrinology. ;Montreal Neurological Inst. (Quebec). Neuroanatomy Lab.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/020;
Stock Number PB92-143924
Additional Subjects Glial fibrillary acidic protein ; Hypothalamus ; 5-7-dihydroxytryptamine ; Rats ; Astrocytes ; Serotonin ; Radioimmunoassay ; Immunohistochemistry ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-143924 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/28/1992
Collation 5p
Abstract
The distribution and level of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Seven days after unilateral intrahypothalamic injection of the 5-HT neurotoxic, 5,7-dihydroxytryptamine, there was a marked increase in the number of GFAP-labelled astrocytes in the ipsilateral hypothalamus of 5,7-DHT-treated as compared to sham-treated rats. Measurement of GFAP levels demonstrated a significant increase on the ipsilateral side of 5,7-DHT-treated rats as compared to sham-treated rats.