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RECORD NUMBER: 27 OF 35

OLS Field Name OLS Field Data
Main Title Radiation- and Chemically-Induced Chromosome Aberrations in Mouse Oocytes: A Comparison with Effects in Males.
Author Tease, C. ;
CORP Author Medical Research Council, Chilton (England). Radiobiology Unit.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/179 ; OHEA-R-482
Stock Number PB93-194462
Additional Subjects Oocytes ; Chromosome aberrations ; Biological radiation effects ; Mutagens ; Comparison ; Mice ; Translocation(Genetics) ; Males ; Females ; Germ cells ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB93-194462 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/23/1993
Collation 10p
Abstract
Data from studies on radiation-and chemically-induced chromosome aberrations in mouse oocytes have been summarized. An attempt has been made to assess the relative sensitivity to mutagenic agents of female and male germ cells through comparison of observations from mutation studies of female and male mice. No unequivocal evidence of a mutagenic effect limited to a single sex could be found in the cytogenetic data, although differences in relative germ cell sensitivity could be inferred for ionizing radiation and some chemicals. However, the pattern of inter-sex variations was not consistent: for example, irradiation of dictyate oocytes yielded a lower rate of heritable chromosome translocations than the same dose to spermatogonia; in contrast, some chemicals, such as mitomycin C, yielded a larger incidence of chromosome anomalies after treatment of dictyate oocytes than spermatogonia. Overall, the limitations in quality and quantity of cytogenetic data, and the uncertainties associated with comparing information obtained in disparate assays, place severe constraints on the use of observations on induced chromosome aberrations to assess the relative sensitivities of female and male germ cells to environmental mutagens. (Copyright (c) 1992 Elsevier Science Publishers, B.V.)