Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 3

OLS Field Name OLS Field Data
Main Title Nine 'In Vitro Mutagenesis Studies' and Three 'Salmonella/Microsome (AMES) Bacterial Studies' with Cover Letter dated 07/28/1988.
CORP Author Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1988
Report Number FYI-OTS-0888-0630
Stock Number OTS0000630
Additional Subjects Toxicology ; Health effects ; Ethyleneamines ; Acute toxicity ; Geotoxicity ; Gene mutations ; Mammals ; Hamsters ; In vitro ; DNA effects ; Rats ; Chromosomal effects ; Bacteria ; Mice ; Parenteral ; Intraperitoneal ; CAS No 112-24-3 ; CAS No 112-57-2 ; CAS No 140-31-8 ; CAS No 27308-78-7
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Status
NTIS  OTS0000630 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/09/2010
Collation 535p
Abstract
Tetraethylenepentamine (TEPA) was evaluated for potential mutagenic activity with a battery of three in vitro tests, which were: the Chinese Hamster Ovary (CHO) Uutation test, the Sister Chromatid Exchange (SCE) test and an assay for induction of Unscheduled DNA Synthesis (UDS) in rat liver cells. The results indicated that the sample of TEPA produced a significant effect on primary DNA damagge assessed in the ECE and UDS tests but TEPA did not increase the frequency of gene mutations in the CHO Mutation test. The observation of a positive response in two of the three tests suggested that the complex mixture containing TEPA should be considered a weakly active mutagenic agent for mammalian cells in vitro. Because this sanple was a mixture which contained numerous other components, the present tests cannot discriminate whether TEPA itself or one or more components produced the positive responses. These results should be considered an indication of the potential activity of this material and they suggest the need for other tests to investigate the biological significance of the observations of this study.