Abstract |
The clastogenic potential of di-n- butylamine (CAS No. 111-92-2) was evaluated by incidence of micronucleated polychromatic erythrocytes in bone marrow of Harlan Sprague-Dawley ICR mice (20/sex/group) administered single oral gavage doses at 55, 110, or 220 mg/kg bodyweight. Mortality occurred among high-dose males (3/20) and females (1/20), and lethargy was observed in both males and females of all treatment groups. While treated mice exhibited slight reductions in polychromatic erythrocytes to erythrocyte ratios (up to 19%) relative to vehicle control (corn oil) animals, there was no significant increase in micronucleated polychromatic erythrocytes at 24, 48 or 72-hour post-treatment examination in either male or female treated mice when compared to controls. |