Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Status of Monsanto's Phosphate Fiber (Calcium Sodium Metaphosphate) Toxicology Testing Program and EPA Response Letters.
CORP Author Monsanto Chemical Co., Akron, OH.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 7 Mar 1986
Year Published 1986
Report Number FYI-OTS-0386-0486;
Stock Number OTS-0000486-0
Additional Subjects Carcinogenicity ; Toxicity ; Phosphate fibers ; Rats ; Laboratory animals ; Implants ; Calcium sodium metaphosphate ; Intrapleural implantation ; Gelatin pledgets ; Peural sarcomas ; Chrysotile asbestos ; CAS No. 23209-59-8
Library Call Number Additional Info Location Last
NTIS  OTS-0000486-0 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/08/2007
Collation 167p
On a For Your Information (FYI) basis, the Monsanto Company submitted information concerning the conduct and preliminary findings from a recently completed intrapleural implantation study of calcium sodium metaphosphate (CAS No. 23209- 59-8) fibers in rats: 'In this test,. . .(calcium sodium metaphosphate) fibers in gelatin pledgets were surgically implanted in the pleural space of experimental rats. Each of 3 groups consisted of approximately 75 males and 75 females at the outset; sub-groups of 5 males and 5 females from each group were sacrificed at 6, 12, and 18 month inter- vals. No (calcium sodium metaphosphate) fiber-induced fibrosarcomas were detected at these interim periods. After the final sacrifice at 24 months, 3 of the 120 (calcium sodium metaphosphate fiber-exposed) animals had fibrosarcomas. Also, at the final sacrifice in the positive control group, in which chrysotile asbestos had been implanted, 5 of 121 animals had fibrosarcomas. In the negative control group, no fibrosarcomas were ob- served.'