Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title In vitro Approaches for Determining Mechanisms of Toxicity and Carcinogenicity by Asbestos in the Gastrointestinal and Respiratory Tracts.
Author Mossman, B. T. ;
CORP Author Vermont Univ., Burlington. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-68-03-3130; EPA/600/J-83/261;
Stock Number PB85-110492
Additional Subjects Asbestos ; Toxicology ; In vitro analysis ; Gastrointestinal system ; Respiratory system ; Exposure ; Reprints ; Carcinogenesis ; Air pollution effects
Library Call Number Additional Info Location Last
NTIS  PB85-110492 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
Organ and cell cultures of gastrointestinal and tracheobronchial epithelium have been used to document both the interaction of asbestos with mucosal cells and the sequence of cellular events occurring after exposure of cells to fibers. The biological activity of various types of asbestos in vitro is related to surface charge, crystallization and dimensional characteristics. These factors also influence adsorption of natural secretions and serum components to fibers, a process which ameliorates cytotoxicity. Although mechanistic studies at the cellular level are lacking using epithelial cells of the digestive tract, asbestos appears to elicit a constellation of morphologic and biochemical changes in tracheal epithelium that resemble effects of classical tumor promoters on target cells.