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RECORD NUMBER: 12 OF 48

OLS Field Name OLS Field Data
Main Title Dimethyltin Dichloride: Investigations into Its Gastrointestinal Absorption and Transplacental Transfer.
Author Noland, E. A. ; McCauley, P. T. ; Bull, R. J. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1983
Report Number EPA-600/J-83-220;
Stock Number PB84-213149
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Absorption ; Gastrointestinal system ; Reprints ; Dimethyltin dichloride ; DMDC ; Water pollution effects(Animals)
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB84-213149 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 12p
Abstract
Dimethyltin dichloride (DMDC) is commonly used as a stabilizer in PVC pipe used for transport of potable water. Learning deficiencies have been observed postnatally in pups from DMDC-treated dams. Studies were conducted with female Sprague-Dawley rats to determine whether DMDC was absorbed by the dam and transferred across the placenta to fetal blood and brain tissue. This was accomplished in three phases: (1) a comparison of absorption of organic and inorganic tin from drinking water, (2) a comparison of prenatal and postnatal levels of tin in the pups in cross-fostering studies, and (3) a (14C)dimethyltin dichloride tracer study to determine whether organic tin passed to the pup intact. Major findings include: (1) DMDC is absorbed in the gastrointestinal tract of the dam much more rapidly than Sn2+; (2) the more rapid absorption of DMDC results in higher concentration of tin in fetal blood and brain; and (3) in fetuses that receive tin as DMDC, both tin and the methyl carbon are absorbed by the dam and transferred to the blood and brain of the fetuses.