Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of endogenous ammonia on neutralization of inhaled sulfuric acid aerosols /
Author Loscutoff, Susan M.,
CORP Author Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Cincinnati, OH.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Available to the public through the National Technical Information Service.
Year Published 1979
Report Number EPA-600/1-79-045; EPA-68-03-2665
Stock Number PB80-147978
OCLC Number 06368204
Subjects Sulfuric acid--Toxicology. ; Ammonia. ; Aerosols. ; Inhalation. ; Gases, Asphyxiating and poisonous. ; Sulfuric Acids. ; Sulphuric acid--Toxicology
Additional Subjects Sulfuric acid ; Ammonia ; Toxicology ; Sulfates ; Dogs ; Respiration ; Exposure ; Laboratory animals ; Concentration(Composition) ; Aerosols ; Lung ; Toxic substances ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJAD  EPA 600/1-79-045 Region 3 Library/Philadelphia, PA 10/11/1996
EJBD ARCHIVE EPA 600-1-79-045 Headquarters Library/Washington,DC 01/04/2013
EJBD  EPA 600-1-79-045 Headquarters Library/Washington,DC 04/23/2014
EKAM  EPA-600/1-79-045 Region 4 Library/Atlanta,GA 12/03/1999
EKBD  EPA 600/1-79-045 Research Triangle Park Library/RTP, NC 04/17/2019
NTIS  PB80-147978 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation x, 38 pages : illustrations.
Nine male beagle dogs were exposed by inhalation to 0, 6 and 10.5 mg/cu.m sulfuric acid aerosols with normal ammonia, increased blood ammonia, and increased inhaled ammonia to determine whether the addition of ammonia affected the toxicity of sulfuric acid aerosols. Exhaled concentration of ammonia, sulfuric acid and ammonium bisulfate were measured to determine the neutralization of inhaled aerosol by ammonia in the lung. Unneutralized sulfuric acid aerosol was detected in exhaled air only during exposure to 10.5 mg/cu.m H2SO4 with approximately 25 percent of the total exhaled sulfate measured as H2SO4. No unneutralized H2SO4 was measured after a tenfold increase in blood ammonia by ammonium acetate infusion. Increased blood ammonia resulted in a slightly decreased irritant effect of 10.5 mg/cu.m H2SO4 in the lung using residual volume and functional residual capacity as endpoints. The results indicate that neutralization of inhaled sulfuric acid aerosols can be increased by increasing blood ammonia concentrations. However, the increased neutralization does not seem to markedly affect the toxicity of the inhaled and aerosols.
"Biology Department, Battelle Memorial Institute, Pacific Northwest Laboratories." Dec. 1979. Includes bibliographical references (pages 36-37). "Contract No. 68-03-2665."