| Main Title |
Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex. |
| Author |
Crofton, K. M. ;
Reiter, L. W. ;
Mailman, R. B. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/050; |
| Stock Number |
PB87-212445 |
| Additional Subjects |
Insecticides ;
Toxicology ;
Rats ;
Ligands ;
Synapses ;
Hazardous materials ;
Reprints ;
Pyrethrins ;
Neurotoxins ;
Receptors(Gaba-benzodiazepine) ;
FLU(Flunitrazepam) ;
TBPS(t-butylbicyclophosphorothionate) ;
MUS(Muscimol)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-212445 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Radioligand binding displacement studies were conducted to determine the effects of Type I and II pyrethroids on (3H)-flunitrazepam (FLU), (3H)-muscimol (MUS), and (35S)t-butylbicyclophosphorothionate (TBPS) binding. Competition experiments with (3H)-FLU and (3H)-MUS indicate a lack of competition for binding by the pyrethroids. Type I pyrethroids failed to compete for the binding of (35S)-TBPS at concentrations as high as 50 pM. Type II pyrethroids inhibited (35S)-TBPS binding to rat brain synaptosomes with Ki values ranging from 5-10 pM. The data presented here suggest that the interaction of Type II pyrethroids with the GABA receptor-ionophore complex is restricted to a site near the TBPS/picrotoxinin binding site. |
