Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex.
Author Crofton, K. M. ; Reiter, L. W. ; Mailman, R. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Year Published 1987
Report Number EPA/600/J-87/050;
Stock Number PB87-212445
Additional Subjects Insecticides ; Toxicology ; Rats ; Ligands ; Synapses ; Hazardous materials ; Reprints ; Pyrethrins ; Neurotoxins ; Receptors(Gaba-benzodiazepine) ; FLU(Flunitrazepam) ; TBPS(t-butylbicyclophosphorothionate) ; MUS(Muscimol)
Library Call Number Additional Info Location Last
NTIS  PB87-212445 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 10p
Radioligand binding displacement studies were conducted to determine the effects of Type I and II pyrethroids on (3H)-flunitrazepam (FLU), (3H)-muscimol (MUS), and (35S)t-butylbicyclophosphorothionate (TBPS) binding. Competition experiments with (3H)-FLU and (3H)-MUS indicate a lack of competition for binding by the pyrethroids. Type I pyrethroids failed to compete for the binding of (35S)-TBPS at concentrations as high as 50 pM. Type II pyrethroids inhibited (35S)-TBPS binding to rat brain synaptosomes with Ki values ranging from 5-10 pM. The data presented here suggest that the interaction of Type II pyrethroids with the GABA receptor-ionophore complex is restricted to a site near the TBPS/picrotoxinin binding site.