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OLS Field Name OLS Field Data
Main Title Comparison of Screening Approaches.
Author Tilson., H. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher 1991
Year Published 1991
Report Number EPA/600/D-91/116;
Stock Number PB91-199851
Additional Subjects Toxicity ; Nervous system ; Toxic substances ; Animal behavior ; Evoked potentials ; Locomotion ; Senses ; Autonomic nervous system ; Dose-response relationships ; Environmental pollutants ; Functional observational battery(FOB)
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB91-199851 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1991
Collation 36p
Abstract
Procedures used to identify or screen for the presence of neurotoxicity are usually designed to test large numbers of animals and are not considered to be as sensitive to subtle effects as more specialized tests for neurobiological dysfunction. For purposes of screening, the use of a functional observational battery (FOB) is now generally accepted. A number of batteries containing different observations and measurements have been developed in several laboratories for rodents, dogs, and non-human primates. FOB used in screening typically assess several neurobiological domains including neuromuscular (i.e., weakness, incoordination, abnormal movements, gait, motor seizures, myoclonia, rigidity and tremor), sensory (i.e., auditory, visual and somatosensory) and autonomic (i.e., pupil response, salivation) functions. Most FOB used for screening do not assess cognitive function (i.e., learning and memory). FOB evaluations can yield important information concerning dose-response characterizatics and data on the onset, duration and persistence of an effect. FOB should be able to differentiate neurotoxicants from non-neurotoxicants and neurotoxicants having different mechanism(s) or site(s) of action.