||Assessment of toxicity of automotive metallic emissions. volume II, Relative toxicities of automotive metallic emissions against lead compounds using biochemical parameters /
Holbrook, David J.
||North Carolina Univ., Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, N.C.
|| U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Automobiles--Motors--Exhaust gas--Environmental aspects. ;
Palladium inorganic compounds ;
Lead inorganic compounds ;
Platinum inorganic compounds ;
Manganese inorganic compounds ;
Fuel additives ;
Physiological effects ;
Ribonucleic acids ;
Laboratory animals ;
Deoxyribonucleic acids ;
Experimental data ;
Exhaust gases ;
Dose rate ;
Lethal dosage ;
Toxic hazards ;
Environmental health ;
Automobile exhausts ;
Catalytic reactors(Exhaust systems)
||Region 3 Library/Philadelphia, PA
||Region 4 Library/Atlanta,GA
||Research Triangle Park Library/RTP, NC
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||vii, 59 pages ; 28 cm.
Platinum and palladium compounds currently are being used as the active components in the catalytic converters of air pollution control devices on many motor vehicles. It is of interest, therefore, to determine the biological effects of the compounds of these metals. Results of intraperitoneal (IP) administration of PtCl4 or Pd(NO3)2 are reported. Administration at levels of 28 or 56 moles/kg body weight decreased the thymidine incorporation into DNA of spleen, liver, and testis. Effects of various salts of platinum or palladium administered by intraperitoneal injection or ingestion were determined on the parameters of the microsomal mixed function oxidase system from rat liver. Lethal-dose studies are reported following the intraperitoneal or oral administration of salts of lead, manganese, platinum, and palladium to young male rats.
"EPA/600-1-76-010b." "January 1976." Contract No. 68-02-1701. EPA project officer: Frances P. Duffield. Includes bibliographical references (page 49).