Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Dietary Lipid and Dimethyl Sulfoxide on Lindane Metabolism.
Author Chadwick, R. W. ; Simmons, W. S. ; Bryden, C. C. ; Chung, L. T. ; Key., L. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Year Published 1976
Report Number EPA/600/J-77/092;
Stock Number PB-278 597
Additional Subjects Pesticides ; Chlorobenzenes ; Lipids ; Methyl sulfoxide ; Metabolism ; Dosage ; Diet ; Fatty acids ; Rats ; Bioassay ; Laboratory animals ; Food consumption ; Growth ; Excretion ; Ribosomes ; Toxicity ; Insecticides ; Lindane ; Bioaccumulation
Library Call Number Additional Info Location Last
NTIS  PB-278 597 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 21p
Previous investigations have suggested that there is a requirement of dietary polyunsaturated fatty acids for full expression of microsomal enzyme induction. The conclusions in these studies were primarily based on in vitro enzyme activity, sleeping time recovery, or hepatic cytochrome P-450 content, measured 24 hr after treatment with an inducing agent. This study examines the influence of dietary lipids, containing different fatty acid compositions, on the storage and self-induction of lindane metabolism. Depressed food consumption and growth rate, an impaired metabolite excretion pattern, low specific microsomal phospholipid content and a decreased microsomal PC/PE ratio containing a reduced proportion of polyunsaturated fatty acids suggested that a toxic Lindane-DMSO-Dietary lipid interation had occurred.