||Neurobehavioral assessment of workers exposed to organophosphorus pesticides /
Otto, David. ;
Soliman, S. ;
Svendsgaard, D. ;
Soffar, A. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Alexandria Univ. (Egypt). ;Tanta Univ. (Egypt). School of Medicine.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Peripheral nerve diseases ;
Occupational exposure ;
Organophosphate insecticides ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||38 pages ; 28 cm
Workers (N=229) from an Egyptian pesticide formulation plant were screened for signs of organophosphorous induced delayed polyneuropathy. Tests included lymphocyte neuropathy target esterase (LNTE), serum cholinesterase, tactile sensitivity, block design (BD) and Santa Ana Dexterity (SAD) tests. Workers from fertilizer (N=181) and textile (N=166) plants were tested as controls. A one-year follow-up evaluation of workers was also conducted. LNTE activity levels of pesticide formulators were significantly lower than levels of education (inverse relationships) after controlling for age and LNTE activity. Tactile threshold increased linearly with age. BD and SAD scores did not vary with LNTE or among plants. Results suggest that tactile sensitivity testing may provide a useful method for early detection of peripheral neuropathy in workers exposed to pesticides.
"The information in this document has been funded wholly or in part by the US EPA under cooperative agreement CR-811170 to Dr. Salah Soliman." Includes bibliographical references. "EPA/600/D-89/151"--Cover. "Presented at the Proceedings of the Third International Symposium on Neurobehavioral Methods in Occupational and Environmental Health, 1989." Microfiche.