Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 308

OLS Field Name OLS Field Data
Main Title 7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid).
Author Joyce, N. J. ; Daniel, F. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-275;
Stock Number PB83-163477
Additional Subjects Carcinogens ; Deoxyribonucleic acids ; Rats ; Liver ; Deoxyribonucleic acids ; Parenteral infusions ; Chemical analysis ; Fluorescence ; Aromatic polycyclic hydrocarbons ; Malignant neoplasms ; Reprints ; Benzanthracene/dimethyl ; Benzanthracene/hydroxymethyl-dimethyl ; High performance liquid chromatography ; Cancer
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-163477 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract
The polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA) is a potent carcinogen to the female Sprague-Dawley rat, and when administered under conditions that have been shown to produce cancer, results in extensive formation of hydrocarbon-deoxyribonucleoside adducts. Sephadex LH-20 and reverse-phase h.p.l.c. and spectrofluorometric analysis of these adducts demonstrate that at least one adduct results from the binding of 7,12-dimethylbenz(a)anthracene-1,2,3,4-tetrahydro-3,4-dihydroxy-1,2-oxide.