Record Display for the EPA National Library Catalog

RECORD NUMBER: 370 OF 3914

OLS Field Name OLS Field Data
Main Title Attempts to Abbreviate Time to End-Point in Fish Hepatocarcinogenesis Assays.
Author Couch, J. A. ; Courtney, L. A. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL.
Year Published 1984
Report Number EPA/600/D-84/229;
Stock Number PB84-246297
Additional Subjects Carcinogens ; Toxicity ; Marine fishes ; Exposure ; Diethylamine ; Nitroso compounds ; Sampling ; Damage assessment ; Bioassay ; Liver ; Histology ; Electron microscopy ; Diethylamine/N-nitroso ; Cyprinodon variegatus ; Lesions
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB84-246297 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 43p
Abstract
Adult and juvenile Cyprinodon variegatus were exposed to relatively high sub-lethal concentrations of the potent carcinogenic agent, N-nitrosodiethylamine (DEN). Fish were exposed for several weeks under static conditions to initial DEN concentrations of 55 mg/l, dropping to 30 mg/l at exposure's end. Fish were then transferred to clean flow-through water for holding, observation, and characterization of lesion development. Progression of the hepatic effects of DEN is being followed by periodic sampling for histochemistry, histology, and electron microscopy. The earliest damage in the liver was assessed and subsequent progression of lesions is being monitored.