||Inhibition of Gap-Junctional Intercellular Communication between Chinese Hamster Lung Fibroblasts by Di (2-Ethylhexyl) Phthalate (DEHP) and Trisodium Nitrilotriacetate Monohydrate (NTA).
Malcolm, A. R. ;
Mills., L. J. ;
||Environmental Research Lab., Narragansett, RI. ;Science Applications International Corp., Narragansett, RI.
Intercellular junctions ;
Trisodium nitrilotriacetate monohydrate ;
Chinese hamsters ;
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Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication in vitro correlate with their tumor-promoting activity. Such results further support the hypothesis that inhibition of gap-junctional communication is an in vitro biomarker for some tumor-promoting chemicals. (Copyright (c) 1989 Princeton Scientific Publishing Co.)