Record Display for the EPA National Library Catalog

RECORD NUMBER: 20 OF 93

OLS Field Name OLS Field Data
Main Title Developmental Toxicity of Dinocap in the Mouse is not Due to Two Isomers of the Major Active Ingredients (Journal Version).
Author Rogers, J. M. ; Gray, L. E. ; Carver, B. D. ; Kavlock, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/415;
Stock Number PB89-105852
Additional Subjects Toxic substances ; Fungicides ; Teratogens ; Fetus ; Isomers ; Laboratory animals ; Nitrogen organic compounds ; Prenatal exposure delayed effects ; Pregnancy ; Cleft palate ; Fetal viability ; Body weight ; Otoliths ; Reprints ; Dinocap ; Butenoic acid/methyheptyl-dinitrophenyl ester
Holdings
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Status
NTIS  PB89-105852 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 8p
Abstract
The developmental toxicities of 2,4-dinitro-6-(1-methylheptyl)phenyl crotonate and 2,6-dinitro-4-(1-methylheptyl)phenyl crotonate, model isomers of the major active ingredients of technical dinocap, were compared to the known teratogenicity of the technical compound. Individual isomers, both isomers combined, or technical dinocap were administered to pregnant mice on days 7-16 of gestation. Similar to previous studies, technical grade dinocap caused cleft palate and weight deficits in fetuses at term and increased neonatal mortality and abnormal swimming behavior, torticollis, and deficient otolith formation in surviving pups. Neither of the purified isomers exhibited any developmental toxicity when administered under identical conditions. Thus, it is concluded that these isomers are not the active teratogenic component(s) in technical grade dinocap.