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OLS Field Name OLS Field Data
Main Title Initial Submission: a Developmental Toxicity Study with Aminomethylphosphonic Acid in Rats (Final Report) with Cover Letter dated 07/10/92.
CORP Author Monsanto Co., Alvin, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920004838
Stock Number OTS0540915
Additional Subjects Toxicology ; Health effects ; Aminomethylphosphonic Acid ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 1066-51-9
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NTIS  OTS0540915 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 266p
Abstract
Aminomethylphosphonic acid (CAS No. 1066-51-9) was evaluated for developmental effects in groups of 25 female Charles River rats administered the test substance by gavage at dose levels of 0, 150, 400, or 1000 mg/kg/day in a constant dose volume of 10 mL/kg in corn oil on days 6 through 15 of gestation. Animals were sacrificed on day 20 of gestation. Clinical signs of toxicity at 400 and 1000 mg/kg/day included mucoid feces, hair loss and soft stool. Mean body weight gain was slightly reduced during days 12 through 16 of gestation at 1000 mg/kg/day (p<0.05). The 1000 mg/kg/day group showed slightly decreased mean fetal body weight. No treatment related fetal malformations or developmental variations were observed at any of the dose levels. The NOAEL was 150 mg/kg/day.