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RECORD NUMBER: 49 OF 256

OLS Field Name OLS Field Data
Main Title Initial Submission: 90-Day Inhalation Toxicity Study of Phenylphosphine in Rats and Dogs with Cover Letter dated 10/15/1992.
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-1092-11456
Stock Number OTS0571394
Additional Subjects Toxicology ; Health effects ; Acute toxicity ; Phenylphosphine ; Subchronic toxicity ; Rats ; Inhalation ; Dogs ; Reproduction ; Fertility effects ; CAS No 638-21-1
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NTIS  OTS0571394 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/27/2010
Collation 57p
Abstract
Young adult male and female rats and male beagle dogs were exposed to phenylphosphine for six hours daily, five days per week, for a total of 59 exposures. Two test levels and a control were used. The test levels were designed as 0.3 and 3.0 ppa (viv), but averaged 0.6 and 2.2 ppm over the 90-day period. At 0.6 ppm, mild clinical and hem:tologic effects were observed in some anamals; however, histopathologic examination of tissues revealed no test compound-related effects. Rats exposed to the 2.2 ppm level showed severe clinical, hematological, and histopathologic effects. Dogs exposed at this level vere more affected than those at the lower level; however, they were less severely affected than rats exposed to 0.6 ppm. Testicular degeneration observed in rats at the high level was irreversible, while in dogs it showed a slight reversal. Two and 1/S parts per million (2.2 ppm) phenylphosphine is a definite chronic affect level based on data collected during this study, while 0.6 ppm appears to be a threshold level for effect. The possibility of species differences must always be considered and a more susceptible species may be affected at a lower dose level dban the rats were in this experiment. It follow chat all results cannot be extrapolated to humans, a species for which no phenylphosphine exposure data are available.