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RECORD NUMBER: 47 OF 256

OLS Field Name OLS Field Data
Main Title Initial Submission: 2-propenoic Acid, Butyl Ester: Translation of German Article on Industrial Hygiene and Toxicology Describing Studies in Rats with Cover Letter dated 08/12/92.
CORP Author BASF Corp., Mount Olive, NJ.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920005597
Stock Number OTS0544381
Additional Subjects Toxicology ; Health effects ; Butyl Ester ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 141-32-2
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NTIS  OTS0544381 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 29p
Abstract
N-butyl acrylate (CAS No. 141-32-3) was evaluated for developmental toxicity. It was administered to groups of 15 fertilized female rats per group dosed with 0, 25, 135, and 250 ppm for 6 hours per day by inhalation on days 6-15 of gestation. Body weight gain was reduced by 95% at 135 ppm or above. There were no deaths in any of the test groups. Conception rate, corpora lutea, or weight of placentas were not affected by treatment. The percent of live implants per pregnant rat were reduced by 95% relative to controls. The number of dead implants per pregnant rat was increased in comparison to controls (significance 99%). The number of early resorptions increased at 135 ppm or above (statistical significance was not reported). Medium-late resorptions were increased in all test groups (statistical significance was not reported). No late resorptions were observed in any of the test groups. The percentage of dead implants per pregnant rat was increased by 99% relative to controls. The weight of male fetuses was increased by 95% relative to controls. The weight of female fetuses was not altered by treatment. The length of the fetuses was larger on the average by 99% at 25 ppm or above. Anomalies, variations and/or retardations observed in treatment groups were not different from controls. It was concluded that the toxic dose was between 25 and 135 ppm.