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RECORD NUMBER: 43 OF 256

OLS Field Name OLS Field Data
Main Title Inhalation Teratology Study in Rabbits with Nitrobenzene (Final Report).
CORP Author Bio-Dynamics Research and Development Corp., Eugene, OR.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8424492
Stock Number OTS0510651
Additional Subjects Toxicology ; Health effects ; Nitrobenzene ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 98-95-3
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NTIS  OTS0510651 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 370p
Abstract
The embryotoxicity and teratogenicity of nitrobenzene were evaluated in mated female New Zealand White rabbits (22/group) exposed by inhalation to nitrobenzene at nominal concentrations of 0, 10, 40 or 100 ppm for 6 hrs/day during gestation days (GD) 7-19. The animals were sacrificed on the day evidence was observed that they aborted or delivered prematurely or on GD 30, whichever occurred sooner. Significant differences between treated and control animals were observed in the following: increased absolute and relative liver weight and methemoglobin values (mid- and high-dose groups). No significant differences between treated and control animals were observed in the following: mortality, pregnancy, abortion or premature delivery rates, body weights, corpora lutea and uterine implantation data, fetal weight, crown-rump distance, fetal sex distribution, and external, visceral and skeletal evaluation of fetuses.