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RECORD NUMBER: 28 OF 256

OLS Field Name OLS Field Data
Main Title Evaluation of Monomethyl Formamide, Dimethyl Formamide and Dimethyl Acetamide for Possible Teratogenic and/or Abortificient Properties, with Cover Letter dated 09/29/1995 (Sanitized).
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1995
Report Number OTS-86960000185S
Stock Number OTS0558325
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Dimethyl acetamide ; Dimethyl formamide ; Laboratory animals ; Reproduction/fertility effects ; Mammals ; Rats ; Oral ; Gavage ; CAS No 68-12-2 ; CAS No 127-19-5
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NTIS  OTS0558325 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/12/2010
Collation 12p
Abstract
Dr. J. B. Thrersch in personal communication (1) indicated his animal research has reported dimethyl acetamide to be an effective abortifacient agent; monomethyl formamide to be a potent teratogenic agent without abortifacient properties; and dimethyl formamide to have no teratogenic or abortifacient activity. Although the details of Thierach's methodology were not available to us, this present test was designed to evaluate the possible abortifacient andfor teratogenic properties of the above compounds when administered orally to rats at several dose levels and at various times during pregnancy.