||Evaluation of Monomethyl Formamide, Dimethyl Formamide and Dimethyl Acetamide for Possible Teratogenic and/or Abortificient Properties, with Cover Letter dated 09/29/1995 (Sanitized).
||Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Toxic substances ;
Dimethyl acetamide ;
Dimethyl formamide ;
Laboratory animals ;
Reproduction/fertility effects ;
CAS No 68-12-2 ;
CAS No 127-19-5
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Dr. J. B. Thrersch in personal communication (1) indicated his animal research has reported dimethyl acetamide to be an effective abortifacient agent; monomethyl formamide to be a potent teratogenic agent without abortifacient properties; and dimethyl formamide to have no teratogenic or abortifacient activity. Although the details of Thierach's methodology were not available to us, this present test was designed to evaluate the possible abortifacient andfor teratogenic properties of the above compounds when administered orally to rats at several dose levels and at various times during pregnancy.