Record Display for the EPA National Library Catalog
RECORD NUMBER: 27 OF 256
|OLS Field Name||OLS Field Data|
|Main Title||Ethyl Acrylate: Inhalation Teratology Study in Rats with Attachments and Cover Letter Dated 07/17/1989 (Sanitized).|
|CORP Author||Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Ethyl Acrylate (140-88-5) ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 140-88-5|
Developmental toxicity was evaluated in groups of 33 female Sprague-Dawley rats receiving whole-body exposure to ethyl acrylate at vapor concentrations of 0, 50, or 150 ppm, for 6 hours/day on gestation days 6-15, followed by fetal examination on gestation day 21. High-dose dams had decreased body weight gain and food consumption, and increased water consumption. The compound was not embryotoxic or fetotoxic. The was a small increase in fetal malformations in the high-dose group, but the difference was not significant.