Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Phenylethyl Alcohol (pea) on Pregnancy of the Rat with Cover Letter Dated 04/18/1986.
CORP Author Huntingdon Research Centre PLC (England).; Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 89-8680232
Stock Number OTS0509772-1
Additional Subjects Toxicology ; Health effects ; Phenylethyl Alcohol ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 60-12-8
Library Call Number Additional Info Location Last
NTIS  OTS0509772-1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 80p
The effects of phenylethyl alcohol (PEA) on the pregnancy of female CrL: COBS CD (SD) BR strain rats (25/control and mid-dose groups, 35/low- and high-dose groups) exposed to PEA by skin painting at dose levels of 0 (water control), 0.14, 0.43 or 1.40 ml/kg/day during days 6-15 of pregnancy were evaluated. The animals were sacrificed on day 20 of pregnancy. Significant differences between high-dose level and control dams were observed in the following: increased clinical observations such as irritability, hunched posture, walking on toes, piloerection and peri-orbital staining, and increased mortality (3/35 animals), decreased body weight gain, decreased levels of creatinine, glutamic-pyruvic transaminase, and increased white cell count. Significant differences between high-dose level and control litter parameters were observed in the following: increased incidence of embryo-fetal deaths (primarily early in pregnancy), decrease in litter size and weight, increased incidence of defects including anophthalmia/microphthalmia, ventricular septal defects, defects/irregularities affecting thorax, and/or kinky tail, defects of the thoracic ribs and occurrence of cervical rib(s). No significant differences between treated and control animals were observed in the following: relative liver and kidney weights, or pregnancy rates. No significant differences between mid- and low-dose level and control groups were observed with respect to maternal toxicity or litter parameters, although a small, dose-dependent increase in some of the morphological parameters was observed in the fetuses of the mid-dose level group.