Record Display for the EPA National Library Catalog
RECORD NUMBER: 23 OF 256
|OLS Field Name||OLS Field Data|
|Main Title||Effect of 2-chlorotoluene Vapour on Pregnancy of the New Zealand White Rabbit with Cover Letter dated 08/19/1983.|
|CORP Author||Huntingdon Research Center, New City, NY.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; 2-chlorotoluene ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Inhalation ; Subchronic Toxicity ; Toxic substances ; Laboratory animals ; CAS No 95-49-8|
2-Chlorotoluene was tested for developmental toxicity in groups of 16 bred female New Zealand white rabbits receiving whole body exposure to nominal vapor concentrations of 0, 1.5, 4, and 10 mg/L for 6 hours/day on gestation days 6-28. At 10 mg/L, lacrimation, salivation, and ptosis was observed during initial exposures. At 4 and 10 mg/L, there was a significant dose-related reduction in food consumption during the treatment period, which resulted in retardation of mean weight gain between the onset of treatment and day 9 of gestation. The treatment had no significant effect on litter size, pre- and post implantation loss, litteror fetal weight, or incidence of skeletal anomalies and variants.