Methyl tertiary butyl ether was evaluated for developmental toxicity in groups of 15 bred female New Zealand white rabbits receiving whole-body exposure to nominal vapor concentrations of 0, 100, 4000, and 8000 ppm for 6 hours/day on days 6-18 of gestation. Maternal mortality was not observed and all does were sacrificed on gestation day 29. A statistically significant (p < 0.01) reduction in food consumption rates was observed at 8000 ppm. Gross necropsy revealed significantly (p < 0.05) increased liver weights at 8000 ppm. There were no differences between control and treatment groups with respect to the number of corpora lutea, early and late resorptions, non-viable fetuses, viable implantations, pre- or post-implantation losses, sex ratios, or fetal malformations (skeletal, external, or visceral).