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RECORD NUMBER: 18 OF 256

OLS Field Name OLS Field Data
Main Title Developmental Toxicity Study of Inhaled Methyl Tertiary Butyl Ether in New Zealand White Rabbits (Final Report) with Attachments and Cover Letter Dated 07/12/1989.
CORP Author Bushy Run Research Ctr; Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8913426
Stock Number OTS0528041
Additional Subjects Toxicology ; Health effects ; Methyl-t-butyl Ether ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 1634-04-4
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NTIS  OTS0528041 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 280p
Abstract
Methyl tertiary butyl ether was evaluated for developmental toxicity in groups of 15 bred female New Zealand white rabbits receiving whole-body exposure to nominal vapor concentrations of 0, 100, 4000, and 8000 ppm for 6 hours/day on days 6-18 of gestation. Maternal mortality was not observed and all does were sacrificed on gestation day 29. A statistically significant (p < 0.01) reduction in food consumption rates was observed at 8000 ppm. Gross necropsy revealed significantly (p < 0.05) increased liver weights at 8000 ppm. There were no differences between control and treatment groups with respect to the number of corpora lutea, early and late resorptions, non-viable fetuses, viable implantations, pre- or post-implantation losses, sex ratios, or fetal malformations (skeletal, external, or visceral).