Record Display for the EPA National Library Catalog
RECORD NUMBER: 150 OF 256
|OLS Field Name||OLS Field Data|
|Main Title||Male Fertility Study of Sprague-dawley Rats Exposed by Inhalation Route to Acetone Cyanohydrin with Cover Letter dated 04/25/1986.|
|CORP Author||Monsanto Environmental Sciences Center, St. Louis, MO.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Acetone Cyanohydrin (75-86-5) ; Reproduction/fertility Effects ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 75-86-5|
Fertility was evaluated in groups male Sprague-Dawley rats (15/group) receiving whole body exposure to acetone cyanohydrin at nominal concentrations of 10, 30 or 60ppm in a dynamic air flow chamber, 6hrs/day, 5days/week for 69 days (48 exposure days). After 48 exposure days, males were mated to three untreated females, exposure continued until the day of the last mating opportunity (58 exposure days). Mated females were sacrificed at mid-term (gestation days 13-15). There was no effect of treatment for all males as indicated by mortality, mean body weights, clinical observations and necropsy observations. The number of live implants and pre- and postimplantation losses were comparable for all females mated with untreated and treated males.