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RECORD NUMBER: 150 OF 256

OLS Field Name OLS Field Data
Main Title Male Fertility Study of Sprague-dawley Rats Exposed by Inhalation Route to Acetone Cyanohydrin with Cover Letter dated 04/25/1986.
CORP Author Monsanto Environmental Sciences Center, St. Louis, MO.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 878216404
Stock Number OTS0510332
Additional Subjects Toxicology ; Health effects ; Acetone Cyanohydrin (75-86-5) ; Reproduction/fertility Effects ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 75-86-5
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NTIS  OTS0510332 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 175p
Abstract
Fertility was evaluated in groups male Sprague-Dawley rats (15/group) receiving whole body exposure to acetone cyanohydrin at nominal concentrations of 10, 30 or 60ppm in a dynamic air flow chamber, 6hrs/day, 5days/week for 69 days (48 exposure days). After 48 exposure days, males were mated to three untreated females, exposure continued until the day of the last mating opportunity (58 exposure days). Mated females were sacrificed at mid-term (gestation days 13-15). There was no effect of treatment for all males as indicated by mortality, mean body weights, clinical observations and necropsy observations. The number of live implants and pre- and postimplantation losses were comparable for all females mated with untreated and treated males.