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RECORD NUMBER: 149 OF 256

OLS Field Name OLS Field Data
Main Title Letter Submitting One Enclosed Teratology Study and One Enclosed Supplementary Study on Isopropanol.
CORP Author British Industrial Biological Research Association, Carshalton (England).; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 86-920000727
Stock Number OTS0535606
Additional Subjects Toxicology ; Health effects ; Isopropanol (67-63-0) ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 67-63-0
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NTIS  OTS0535606 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 183p
Abstract
Isopropanol (CAS No. 67-63-0) was tested for developmental toxicity. The test substance was administered orally in the drinking water at 0, 0.5, 1.25, and 2.5% to pregnant rats (20/group) on gestation days 6-16. The rats were sacrificed on day 20 for examination. Animals in the two highest dose groups had reduced food and water intake, and a decrease in body weight was noted in the 2.5% group. Mean litter weight decreased with increasing concentration, and there was a statistically significant decrease in mean fetal body weight in the two highest groups compared to controls. No evidence of teratogenicity was noted.