Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Letter from Chemical Manufacturers Association to USEPA Regarding Information on the Enclosed Final Reports on 2-mercaptobenzothiazole with Attachments.
CORP Author Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8972396
Stock Number OTS0525082
Additional Subjects Toxicology ; Health effects ; 2-mercaptobenzothiazole ; Environmental Fate ; Biodegradation ; Monitoring ; Environmental Effects ; Chronic Toxicity ; Invertebrates ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Rabbits ; Acute Toxicity ; Fish-freshwater ; Toxic substances ; Laboratory animals ; CAS No 149-30-4
Library Call Number Additional Info Location Last
NTIS  OTS0525082 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 1342p
The biodegradability of 2-mercaptobenzothiazole (2- MBT) under aerobic conditions was determined by assaying concentrations of 14C-carbon dioxide in controlled systems. Quantities of 14C-carbon dioxide released over the 28-day study period as a result of aerobic microbial degradation of 14C-2- mercaptobenzothiazole (14C-2-MBT) showed 0.1 to 0.2 % degradation (the same degradation value obtained in the presence of an inhibitor, sodium azide) of test substance as compared to 78.4% conversion of a reference material (14C-glucose), indicating 2-MBT did not readily biodegrade under test conditions. Batch equilibrium tests of 14C-2-MBT using 3 soil and 3 sediment types indicate its mobility is medium to low in soil and slight to immobile in sediments. An early life-stage exposure (60 days post- hatch) of rainbow trout (Oncorhynchus mykiss) to a measured concentrations of 78 ug/L 2-MBT and higher led to decreased larval length. The estimated Maximum Acceptable Toxicant Concentration (MATC) was between 41 and 78 ug /L (geometric mean MATC = 57 ug/L). Exposure of Daphnia magna for 21 days under flow-through conditions identified a 21-day EC50 of greater than 470 ug/L and MATC (survival) between 240 and 470 ug/L (geometric mean MATC = 340 ug/L). Oral doses of up to 1800 mg/kg/day by gavage to pregnant rats on gestation days 6 through 15 are not teratogenic nor developmentally toxic, but 1200 mg/kg/day and higher induces maternal toxicity (clinical signs, reduced body weight gain and food intake). Similar tests with rabbits led to slight maternal toxicity at 300 mg/kg/day (highest dose tested), but not developmental toxicity nor teratogenicity. Dose-related decreased body weight and food consumption occurred in male rats fed diets containing 8,750 ppm 2-MBT, but no dominant lethal effect was observed.